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by Dr. Roberta Lee, DD., PhD., ND. Science Editor


Doctor's detailed case notes of veterinary application of the heartworm preventative Revolution and the devastating health effects to this Doberman.


Coming from California where we don't have heartworms to the southeast, I knew we would have new protocol. So, I took my eleven year old female Doberman to the vet to get on heartworm prevention for the spring and summer months.


The heartworm test and a full blood panel was done and everything was in fine order.  So, on the 12th of January, my husband, Alexandria and I went back in to get on the Program and Sentinel.  While we were talking with the vet, she suggested that the heartworm preventative Revolution would be easier to use because we wouldn't have to give the tablets.


 I asked what it was and she said that it was for fleas, ticks, and heartworms, and that it was applied to the back of the neck.  With that she left the examining room and came back with a package of Revolution.  She showed it to us, and then applied to my dog!



What I expected was that she was going to only demonstrate how it would be applied "if" we chose to use it.  But to our astonishment she actually applied it to the back of Alexandria's neck.  I wasn't very happy about this, but, I liked our vet so I just let it slide.


Because she had opened the Revolution package we were expected to purchase it.  The cost of the heartworm medicine was $93.00.



It is important to note that my elderly Doberman weighed 53 pounds and it is fair to say that she raised on mostly human food due to our living in countries where canned dog food was not available.  So when she went off her canned food on the 14th of Jan. (2 days after Revolution was applied) I wasn't too concerned.  I had also noticed that she didn't seem as peppy as normal, so I called my veterinarian to see if maybe there was a canine virus going around.  The vet's office said not to their knowledge.


By late afternoon her nose was running, dripping actually.  This concerned me, as I had never seen her do that before.  Also I noticed that she was drooling and then she seemed woozy, not quite stable on her feet and again, for her that just isn't right.  Even at 11, she is quick, nimble and active.  I was concerned but thought it was a passing thing like when she eats grass.


When that night I went into the kitchen, she had had diarrhea on the kitchen floor.  I was shocked.  I cleaned it up, put her back to bed, and went back myself.  When I got up in the morning she had had diarrhea in three different places.


I took her outside and had to help her stand to urinate.  I got her back in the house, called the vet, and said I was on the way.  That was on the 15th (3rd day after Revolution) and the vet said that she just had a bug and would be all right.  She did not run any tests but suggested that I give Alexandria Imodium for the diarrhea and put her on soft food. The Imodium made her vomit.  So I put her on Pepto Bismol.  She picked at the boiled chicken that I fixed for her but had no appetite and only ate a little to please me.  That it really worried me.


On February 4, 2000 (22 days after her first dose of the heartworm preventative Revolution), I took her back in and said that we had to do something, she was losing weight rapidly.  Actually, She weighed 45 pounds.  In two weeks she had lost 8 pounds.  The vet ran a CBC on her resulting in the following values:


WBC........  4.5/L                       MCV...........60

RBC.........  5.54                        MCH..........20.3

HGB........ 11.2/L                       MCHC.......33.9/L

HCT........ 33.1/L                       RDW..........17.2/H

PLT........156/L                          MPV..........11.3/H



LYM........13.9                         LYM...........0.6/L

MON....... 5.0                          MON..........0.2/L

GRA.......81.1                          GRA...........3.7


ALB.......2.0/L     ALP.......399/H     CA++....12.8/H


X-rays were were normal with the exception of an enlargement of the spleen.


We were sent home with new dog food.  The vet said that she suspected cancer, that the bone marrow had quit making the red blood cells and that we were indeed in trouble.  At this time, I asked if it could be something else and mentioned the Revolution heartworm medication.  I told her that Alexandria had been healthy, active and happy until she received the application of the Revolution.


 The vet very adamantly said, "No."  At this time Alexandria weighed 42 pounds. She was given a steroid injection to help stimulate the manufacture of the RBC's.



Feb.7 (25 days since Revolution) Alexandria is now weighing only 40 pounds - down from 53 pounds - when we went in for a check up and another blood test.


Hemoglobin.......9.8/L                  Absolute Polys..........1984/L

Hematocrit.......28.8/L                  Absolute Bands.........0

WBC................3.2/L                   Absolute Lymphs.......512/L

RBC.................4.72/L                 Absolute Monos.........544

MCV...............61                         Absolute Eos..............168

MCHC............34.8                      Absolute Basos..........0

MCH..............20.8                       Reticulocytes.............0.0/L


This is the report that was sent back with the blood test results:



Microscopic Description: there is no visual evidence of regeneration of the anemia, but this should be evaluated with a reticulocyte count.  Though low in number, the WBC distribution appears fairly normal with podominantly segs, lesser lymphs and few monocytes and eosinophils.  Some of the lymphs are reactive.  Platelet numbers appear to be low normal.


Diagnosis: No specific abnormalities found.

Comment: ////

Jan L. VanSteenhouse, D.V.M., PH.D., Dip. A.C.V.P.


On Feb.13 (31 days after Revolution) we went back to the vets for more blood work. 

Hemoglobin.........10.6/L                         Hematocrit..........33.7/L

Everything else was in the normal range. Low but normal.


Feb.19, 2000: (37 days after Revolution) blood count profile falling...

Hemoglobin.........9.5/L      Hematocrit.........27.7/L      RBC.................. 4.43/L

All else was in the normal range


Feb.29, (41 days after Revolution) more detailed blood work and office visit

Reticulocytes............ 0.1/L

Alkaline Phosphatase 214/L

Calcium................... 8.6/L

Hemoglobin............. 6.7/L

Hematocirt.............. 19.6/L

RBC....................... 3.4/L


After this test Alexandria was put on steroid pills b.i.d. to stimulate her appetite. They have helped. She was also put on a vitamin called NutriCal. The pills cost $72.00. The NutriCal will cost $36.00


We are still battling the loss of weight. Alexandria still only weighs approximately 45 pounds instead of her normal 53. She has good days and not so good days. Some days she eats up a storm and others I have to hand feed her.


It is my personal opinion that the cause of this problem was a reaction to the Revolution heartworm prevention that was applied without permission.  Because Alexandria is an older dog, it is much harder for her to bounce back.


It has been painful for her, and as the one who loves her more than my own life, I can't even put into words what is has cost me.  Not in the dollars spent, but in the fear, apprehension and despair.  This should not happen. It must not be allowed to happen ever again to anyone's beloved pet.


March 13th a doctor from the Pfizer company called me. She was very nice. She said that they had gotten one of my letters and she wanted to check and see how Alexandria was. She asked if I would mind sending her a copy of the records and offered to pay for the treatment costs.


 I was stunned when I added up the cost to date. It is $1623.91. I don't want people to think that money is the issue. IT WASN'T. But as you know there are people that just couldn't afford this.


It makes the cost of preventing heartworms in terms of the dog's health and the owner's ability to pay, almost as bad as having a beloved dog actually have heartworm disease.


Sadly, Alexandria did not live out the year.  I am reeling but compelled to share this with your readers.  Many Dobermans live much longer and she was healthy and vibrant before the heartworm preventative.



Editor's note: "Dr. Robbie" wrote this in 2004 to share with our readers. Dr. Roberta Lee passed away in 2014 but as a member of the NetPlaces Network Science & Advisory Board her knowledge continues to serve dog owners around the globe.

NOW PLAYING IN VIDEO THEATER, this article inspired a Health Ranger video.  See Prescribing Death (6 minutes) on the sick truth of prescriptions, vaccines and the soaring fatalities which parallel the ever-increasing cost of prescription medications.




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HEARTGARD FAILED! People need to know how this can happen!  How many owners blamed themselves when their dogs got a heartworm-positive reading and was on preventative, thought maybe they missed a dose and did NOT file a claim?

PREVENT HEARTWORM MOSQUITOES: "Tiger" mosquitoes, protect your property and dogs from mosquitoes which can carry deadly diseases and cause heartworm disease.


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