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MDR1 Multiple Drug Resistance

by the NetPlaces Network Staff and Subscribers staff notes that occurrences of MDR1, genetic Multiple Drug Resistance, were rarely mentioned in 2021. Breed clubs and veterinary diligence dramatically reduced that genetic defect.


The MDRI flaw found in herding breeds allowed deadly drug reactions to occur and was associated with ivermectin, Heartguard, etc. BUT see current news on food-born multi-drug resistant enterococci at end of this informative background article.


The MDRI flaw found in herding breeds allowed deadly drug reactions.


We recieved this information regarding the “MDR1 flaw (multiple drug resistance deficiency) caused serious drug reactions, even death.  The mission, undertaken in honor of a dog named Buster, was to make a difference in the health and welfare of other herding breed dogs, just like the Amber alert did for children. It appears to have been successful, see NIH (National Institute of Health) link below.


However... dog owners need to be aware of and pay attention to any sign of an adverse reaction to any new medication or as in this example, a canine wormer. Veterinary products go through extensive testing today but any dog can be sensitive or become sensitized to frequently-used medications including heartworm preventatives.


It is important to note that this was NOT JUST IVERMECTIN!!  Also to be grateful that molecular biological research is improving and that herding dog breeders coped with this heroically and of course, geneticically as regards MDR1 - multiple drug resistance deficiency.


In summary, the barrier (P-glycoprotein) that protects the brain by transporting a variety of drugs from the brain tissues back into the capillaries can be flawed. This is the root cause of the disastrous neurological effects, including death, caused by the ingestion of ivermectin. But, IT'S NOT JUST IVERMECTIN, or Avermectin, or the anti-parasitic used in Heartguard or to treat demodic mange.


Be alert for harmful ingredient-components and don't be misled into blaming everything on (someone else's) canine genetics.


A long-time subscriber expressed concerns regarding the following medications that can or have been used in dogs. Flagyl; Rozex; Metrogel, Butorphanol (pain relief after spay/neuter; cough suppressant and canine flu)  Torbutol; Butorphic; Dolorex; Morphasol; Turbogesic Acepromazine (tranquilizer/calming agent and pre-anesthetic)  Ace; ACP; Atravet Cyclosporine or Ciclosporin (allergy immunosuppresant) Sandimmune; Neoral; Cicloral; Gengraf; Restasis, Vinblastine and Vincristine (chemotherapy for cancers & leukemia) cancer regimens called CHOP and Stanford V, Doxorubicin or Adriamycin or Hydroxyldaunorubicin (chemotherapy for cancers & leukemia) Doxil; cancer regimens called ABVD, CHOP, and FAC Loperamide (diarrhea) Imodium; Lopex; Dimor; Pepto, Digoxin (heart ailments) Digitalis (Foxglove) family.


Additionally, neurotoxicity in dogs with the MDR1 genetic flaw may have been caused by: Ondansetron (nausea and vomiting) Zofran; Emeset; Emetron; Ondemet , omperidone (nausea, vomiting, and to stimulate lactation) Motilium, Paclitaxel (cancer) Taxol; Abraxane Mitoxantrone (cancer/leukemia) Etoposide (cancer/leukemia) Eposin; Etopophos; Vepeside; VP-16 Rifampicin or Rifampin (antibiotic - infections, influenza, pneumonia, staph, meningitis) Rifadin; Rifater; Rimactane; Rifinah; Rimactazid Quinidine (heart) Morphine (pain relief, anesthesia, cough suppressant, anti-diarrheal, (shortness of breath)  Domperidone (disorders of the gastrointestinal tract)


The contributors of this information stipulates “any errors or omissions in the above are solely my doing, the credit for most of this information goes to: Washington State University College of Veterinary Medicine,  Veterinary Clinical Pharmacology Laboratory  Pullman, WA”.


PLEASE do not leave it up to your vet to know this ... MDR1 is a matter of life or death. It is also not just Aussies - affected breeds included Collies, Shetland Sheepdogs (Shelties), Australian Shepherds, Old English Sheepdogs, German Shepherds, Long-haired Whippets, Silken Windhounds, Skye Terriers, and a variety of mixed breed dogs.


We thank the alert subscribers who provided much of this information. More in-depth information is covered in Health Testing Hype and Fraud and in the Nat. Institute Of Health Prevalence of the MDR1 gene mutation in herding dog breeds. EST 1998 © Apr 2010-1541710R2201



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