CHG is a fatal canine thyroid problem present in the form of a goiter at birth which also also affects cats, sheep, goats and humans.
May 2019 - Part 4 of veterinary Professor Fyfe's generous contributions to our knowledge of CHG, a rare but 100% fatal condition in newborn puppies.
May 2019 update - click if you missed part 1, the Introduction to CHG, Dr. Fyfe's Part 2 - About Congenital Hypothyroidism with Goiter or Part 3 - CHG-3 Genetic Basis, by Dr. Fyfe
Testing Cost For Congenital Hypothyroidism With Goiter
What is this test for? (link at bottom of page explains genetic basis & cause) The test detects the presence of the gene mutation that causes CHG in multiple dog breeds and other species. Using the test it is possible to identify dogs that are:
How accurate is the test? The test itself identifies the actual disease-causing mutation and is therefore totally reliable in identifying this form of CHG. If, however, a second form of hypothyroidism were to develop in the breed the test would not be able to identify it. Please take every care to follow the submission instructions and ensure that the brushes are labeled correctly.
How do I submit samples for testing? Contact Dr. Fyfe for a test kit. The testing process is very simple. Here is ageneralized example of the procedure...
Editor's note: We ask all breeders to report confirmed CHG diagnosis to our staff AND to Dr. Fyfe
Regarding mention of Toy Fox Terriers or any other "breed statistics" we refer you to this statement: "... and 56 (31%) of 181 TFTs tested to date have been identified as carriers. However, this percentage does not reflect a true carrier prevalence or gene frequency because a large bias in sample submission likely has occurred. In the population sample tested to date, a popular sire effect has been found on the distribution of CHG carriers that is recognized by many breeders and has created a significant motivation for testing." https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1939-1676.2003.tb01323.x (offsite link, copy and paste URL in browser)
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For more information Congenital Hypothyroidism with Goiter, see
Part 1 CHG Introduction Part 2 About CHG and Part 3 - CHG-3 Genetic Basis, by Dr.Fyfe
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