- Global Canine Health Information





Ask your veterinarian about PPA for serious urinary incontinence in older dogs, spayed females or neutered males.






Research notes by Roberta Lee, DD., PhD., ND., Science Editor


Spayed females and neutered dogs tend to “leak” urine, especially upon arising. Frequent urination or leaking is a frustrating problem for owners who want to keep a nice house AND their beloved house dog.


See reference and other links below for housebreaking help but for leaking or uncontrolled urination, see your veterinarian!


Washington:  The U.S. Food and Drug Administration (FDA) isn’t advertising it, but veterinarians can buy phenylpropanolamine (PPA) despite a government-proposed ban of the drug and a recent dry spell in its manufacture.


The key is finding a pharmaceutical company still making it, says Marsha Larkins, ombudsman with the FDA’s Center for Veterinary Medicine (CVM).


In November 2011, FDA officials announced that PPA, a human-approved drug found in weight loss aids and nasal decongestants, eventually would be pulled from the market after a Yale study revealed a link between the drug’s use and hemorrhage stroke in women.


Veterinarians also prescribed the drug off-label to treat bladder control problems and canine urinary incontinence. When FDA officials advised pharmaceutical companies to discontinue PPA production, DVMs lost PPA sources.


But it wasn’t long before at least one manufacturer restarted PPA output. According to Larkins, pharmaceutical companies and veterinarians can apply for regulatory discretion with the FDA’s Center for Drug Evaluation and Regulation (CDER) to purchase or make PPA for canines. The regulatory discretion is temporary and will last until CDER bans the drug or pharmaceutical companies invest in testing PPA as a canine urinary incontinence treatment and receive FDA approval, she says.  The product is available through most veterinary distributors, but some compounding pharmacies, which do not fall under FDA guidelines, also are marketing PPA.


canine incontinence (leaky bladder) in female dogs may be helped by this productIn 2011, the FDA approved Incurin, a new drug that uses estriol (a form of estrogen) to help with urinary incontinence but only in spayed female dogs. It became available 2012 and a quick google search will bring up purchasing information.


The best preventative is DO NOT SPAY OR NEUTER(1) your dog. Among other serious health risks, urinary incontinence and frequent urination is predictable as the dog ages. 


If your dog has urinary incontinence, see your veterinarian for diagnosis and treatment.  Neither you nor your beloved dog have to suffer.


Reference and Related Information Articles:

(1) Spay & Neuter Health Risks    ~    Housebreaking The Puppy    ~    ii Legal Health Information Disclaimer



Instant Information on ii THERAPY vs. CURE


      click to share this article    


ii Health Disclaimer   ~   Mission   ~   Privacy Policy   ~   Disclaimer   ~   ii NetPlaces Network


Become A Charter Member of TheDogPlaceYour $20 Membership supports the world's first dog-site (1998).  Documented, cited, global information for all dog owners is powered by the NetPlaces Network and the internet's first

 International Science & Advisory Board.

Become a Charter Member, Join US Now!