How
Vaccines Dysregulate The Immune System and
Impact Genetic Control Over Disease Expression
5th
Annual Joint American Homeopathic Conference Poster Session 2010
presented
by
Patricia Jordan, DVM, CVA, CTCVH, & Herbology
http://dr-jordan.com/
Classification of Immune Responses Body defense mechanisms
Innate and adaptive immunity
Mucosal Immunity
Cell
mediated responses (Th1)
Lymphocytes, (CD1, CD 2, CD3, CD4, CD8) monocytes- macrophages
and natural killer (NK) cells (principal components) Cytokines
Humoral responses (Th2)
involve soluble
components including immunoglobulins (antibodies) [Igs-IgG, IgM,
IgA, IgE, IgD], class switching, antibody gamma globulins and
complement proteins
Immune
System Components Genetic
Major histocompatibility complex (MHC) system Chromosome, gene,
haplotype, and polymorphism and super gene family molecules.9
MHC genes and include [HLA-A, HLA-B, HLA-C, HLA-DPA 1, HLADPB1,
HLA-DQA1, HLA-DQB1, HLA-DRA and HLADRBI.] MHC region
divided into three regions Class I (HLA-A, B and C) Class II (HLADP,
DQ and DR) and Class III genes encode complement components (C2,
C4 and Factor B), cytokines (TNF-α)
MHC genes display high levels of allelic diversity
Activation of Adaptive Immunity Innate
immunity may trigger
adaptive immune responses thru Antigen processing and
presentation by macrophages and dendritic cells .The evolution
of the immune system is a direct consequence of pathogen-exerted
selection pressure. It is particularly those qualities like
progressive development of humoral and cellular adoptive
immunity, Major Histocompatibility Complex (MHC), variable class
I and class II genes, precise mechanisms of immune recognition
and long-term immune memory that reflect the fundamental
evolutionary advancement of the vertebrate immune system. In
evolution the survival advantage imposed by an extremely
reactive immune system is jeopardized if that system turns
against the host and causes "self" destruction.
Vaccination is
an abnormal pathogen presented in an abnormal route (injection)
and influences the entire immune system in an unnatural way,
leading to unnatural evolutionary selection where the results
are dys regulation of the immune system, disruption of TH1 bias,
atrophy of mucosal, increased inflammation, loss of
specification and control. Vaccination dysregulates the immune
system and genetically impacts the HLA (MHC) leading to an
abnormal expression of disease susceptibility. The vaccine is no
more a reflection of the actual environmental challenges faced
by those vaccinated than the now dysregulated immune system is a
reflection of intelligent design or natural selection. Vaccines
are genotoxic; corrupted genomes are leading to the loss of the
organic self. Vaccines are responsible for autoimmune, cancer,
Type I-IV reactions, allergies, asthma, atopy anaphylaxis,
eczema, organ failure, neurological, behavioral disease and
death.[List is not complete] Vaccine disease is the root of our
dys regulated immune system and the dys regulated immune
response.
Anything
that affects gene coding affects genetic expression of disease
The
evolution of the immune system is a direct consequence of the
pathogens the immune system was exposed to from the environment.
The pathogens exert an evolutionary selection pressure which was
in part responsible for the genotypes of the MHC (major
histocompatibility complexes) that developed in tandem to handle
the pathogens. The MHC determines the host’s immunopathology
impact from the antigen and is responsible for the expression of
clinical disease. The immune system is very complex and
developed to handle an enormous variety of pathogens, the
genetic ability to respond to a large number of pathogens was
necessary in order to survive to live another day.
The MHC
tissue markers are one of the major routes of tapping into the
possible needs for survival via the immune response. Although
not the only way, besides the MHC we have the major loci, minor
loci and many other locations for gene expression to effect
disease expression. We now see the complexity of immune system
response pathways and still there are many factors that remain
unknown. The MHC and the HLA and DLA (yes, dogs also have MHC
sites like the humans) in fact all vertebrates have this
important link of genetic expression of antigen reception and
engagement. The groups of receptor sites not only engage with
the pathogens, they are also responsible for a cascade of events
that have evolved over time to express the organism’s impact
with a pathogen, reflecting in dis ease susceptibility and
genetic expression.
There is
a great variability in how any one individual will react to any
pathogen and it is the individual’s genetic variability that is
the marvel of individual and species survival .Not everyone
would respond the same way to each pathogenic impact. The immune
system, like a virus has great reach with incredible mutation
ability through gene expression and this brings an organism
forward to survive another day.
Vaccines
lead to genetic mutations. Genetic impact on MHC (HLA) is what
dictates genetic expression of disease susceptibility. Vaccines
rob the individual of natural evolutionary selection pressures
based on natural antigen risks. Vaccines are altering gene
sequences, inserting genes, affecting genome and destroying the
organic immunologically determined susceptibility that evolved
with natural selection. Determined susceptibility is
genetically impacted ahead of disease expression by the antigens
presented to or encountered by the individual. The immune system
has evolved naturally to promote life and what is happening with
unnatural antigen environment delivered in unnatural route to
dysregulate the immune system is resulting in unnatural
selection, immune system corruption and species distortion.
The
genetic basis for susceptibility to disease is complex but well
before man understood anything about the immune system and how
it worked, he intruded on the evolved design with a hubris that
is having collateral damage and unintended consequences of
species de evolution.
A
little immunology review;
The
innate immune system was developed to provide the organism with
an immediate response. The natural immune system is composed of
three portions; the first line of defense is the mucosal
immunity and works with the cell mediated immune system (Th1) to
deal with the great majority of pathogens. Entry sites to
the body via the skin, mucosal sites of the nasal/respiratory,
oral/rectal, ocular, aural and urogenital is where the majority
of trials for the immune system would have started. The mucosal
immunity has antiseptic patches of secretory immunoglobulins (IgA)
to respond first. If the mucosal surfaces were actually
penetrated than the IgE immunoglobulins came forth for the
defense.
The cell
mediated responders have evolved to provide the acute
inflammation response which is necessary in properly maturing
the body’s immune system. Without the majority of pathogens
entering from these sites, the immune system does not reach
maturity and therefore is unable to respond competently. The
childhood xanthamatic diseases fulfill this purpose of immune
system maturation. Denied the ability to “mature” the
immune system, the organism is left with a dysfunctional immune
response and genetic disease expression is altered.
Acute
inflammation in the mature immune system can process and
effectively clear the intruder. The hypothesis on how this takes
place is via the dendritic cells instructions to TH1 polarity.
Of course if the dendritic cells are damaged from the vaccine or
the aluminum or the mercury in the vaccines, this is one way the
vaccines dysregulate the polarity of the immune response. The
body needs to be able to focus on the correct form of response
as the body deals with the pathogen. Later, after the invasion
by pathogen has been cleared, the body then engages the humoral
immunity (Th2) to recognize the pathogen and produces antibody
against it. This form of the immune system is the acquired
immune response which vaccinations were meant
to augment. The humoral immunity makes the specific recognizing
antibody after the body is over the acute inflammation so as not
to exhaust the individual and prevent recovery.
Humoral
immunity (Th2) unskewed system is a much different system
designed to deal with pathogens or agents that might penetrate
the skin bypassing the mucosal immunity ex; venoms from
snakebites, poisons or toxins from bites, stings or deep
punctures and microbial injection into areas of low oxygenation
.The humoral system is capable of handling toxin inactivation
and antigen opsonization, dealing with intracellular pathogens
and direction of recognition via antibody production. The
natural immune system never evolved to see immune challenges
enter the body like this. Rarely would a pathogen come into the
immune system’s pristine internal environment of the blood. Humoral immunity was not designed to handle a myriad of
pathogens this route, rather the humoral immunity is an internal
deeper acting immune system for a lesser number of directly
injected pathogens. Parental presentation of the pathogens via
vaccination was not “good shepherding” practice and instead has
been responsible for the improper wiring, signaling and
biochemical pathway disruptions that make up many disorders
today. Again, the wrench thrown into the dynamics of an
evolutionarily successful system by manual manipulations not
based on evolutionary pressure but by medical hubris. Although
pleased with this intervention, man has remained incapable of
understanding the chaos they have created.
The
complex immune system with the spread of genetic variability has
served us well through the beginning of time. Unfortunately,
about 300 years ago an adulteration and violation of the natural
workings of the immune system took place. This adulteration was
the unnatural injection of unnatural pathogens that were not
from the natural environment but rather a concoction of
ingredients made artificially and mixed with toxic chemicals.
Early on the recipe included embalming agents, later with heavy
and light metals, and eventually with genetically engineered
chimeras, man made monsters of unnatural origin.
Many of the
viruses being injected into the bodies are genetically
engineered and certainly not organic. The vaccine has never been
a natural pathogen of the natural environment and never a
natural route of introduction and penetration of the host immune
system. Why would we not foresee the dys regulation,
dysfunction and the accompanied corresponding genetic
compromises and hybridization that explain the growing number of
health issues that have run parallel with the rise in vaccine
number and use?
The
many ways the vaccines dysregulate the immune system and de
construct health. First
imposition of the vaccine is to affect genetic expression of
disease by affording the unnatural engagement of the MHC, the
major HLA then minor loci; cytokine genes, CD-encoding genes, T
cell receptor genes, growth hormone and immunoglobulin genes any
of the polygenes that cascade down to the intricacies of our
many possible gene responses.
Second
imposition of the vaccine is to skew the immune system and
remove the balance of Th1 and Th2 between cell mediated immunity
and humoral immunity. Total dysregulation, shifting of the poles
of immunity which will include a combination of mutations, gene
expression, biochemical pathway alterations, enzyme disruptions,
hijacking the system dys regulation by up regulation of the IgE
expression and a down regulation of the IgA, disruption of the
cytokine profile and many, many other routes depending on the
nature of the pathogen and toxins in the vaccine and the
variable gene response of the individual.
Expression of disease now, is a function of the unnatural
exposure to unnatural pathogens and toxins and the expression of
disease as varied as behavioral, Type I-IV Hypersensitivity;
allergies, asthma, anaphylaxis, atopy, eczema, cancer,
autoimmune, bacterial, viral, yeast, fungal, internal and
external parasites and genetic diseases. The genetic expression
of disease is predated by the link up of the pathogen and the
individual’s gene which are pathogen impact impressionable. The
unnatural selection pressure on the species by the use of
vaccines is unnaturally evolving or de evolving the species
through genotoxicity and genetic disease increase. The
genetic damage or “genetic susceptibility” is transferable to
the next generation. The next generation when vaccinated,
expresses easily the adverse events that vaccines are selecting
for.
The type
of immune response that occurs after pathogen binding is
determined by cytokine messengers that are triggered by certain
elements of the pathogen. The vaccine contains a multiple number
of ways to affect this: contamination with unknown viruses and
microbial components, unnatural pathogens, chimeras and other
genetically engineered products, unfiltered genetic pieces like
virions, prions, viruses from other species, aluminum, mercury
which can directly lead to abnormal cytokine messengers being
produced via pathogen alterations/adulterations/mutations.
Modified live viruses or “attenuated viruses” allow live cells
to migrate to and replicate onto the host’s tissues. Another act
of hubris has occurred because playing with viruses all of these
last 300 years, it was only recently that science has now
discovered that viruses are not dead, they are not live,
they are packets of genetic material that when in the presence
of a susceptible and permissive living cell that has the
necessary receptor can replicate and infect .We have to
remember, the virus affects the appearance of antigen
recognition sites in our MHC system which evolved as a type of
ANTIVIRUS SOFTWEAR SYSTEM.
Sometimes, virus contamination in a vaccine can activate viruses
in the human body 30-40 years after inoculation. The presence of
unknown viruses, the contamination of viruses, the recombination
and reassortment of viral genes and the introduction of
xenotropic viruses, infective DNA viruses have all again - due
to the hubris of man - introduced disease and pathology into
organisms receiving the jab. The process of injecting unnatural
substances into the body started well before the identification
of the fist virus! The contamination continues today with the
filtering process not finding virions and prions and other
smaller genetic impacting contaminants. [Rotavirus vaccine for
children found to contain pig virus]. The viral and even
microbial antigens are all players in the genetic expression of
disease and disease susceptibility to every genome via the MHC
and other still unidentified pathways.
Adjuvants additionally adulterate the intelligence of the innate
immune response. Adjuvants “add” inflammation and pathogen
distortion and therefore cell signaling adulterations,
impingement upon the evolutionarily perfected system and result
in a loss of order. In 1988, Dr. Ron Schultz spoke out in a
roundtable discussion over his concerns of the random addition
to anything into vaccines without understanding in the least the
impact that the addition of for example interleukins into the
vaccines. He framed the impact of the whole body or even just
the immune system as a complete unknown yet the cavalier
attitude from vaccine makers was that no caution was necessary.
We know
now that including interleukin in the vaccines in the 1980’s has
now produced children born to vaccinated populations with the
genetic disease of missing interleukins! The “new” auto
inflammatory syndrome DIRA deficiency of interleukin 1 receptor
agonist where children display a constellation of serious and
potentially fatal systemic symptoms from birth are inherited
mutations in IL IRN
-
a gene that encodes a protein
known as interleukin 1 receptor antagonist. The irony that Dr.
Ian Tizzard would compare the ability to add ingredients like
alum to vaccines used since 1926 and still in l988 not having
any idea how it worked, is little comfort to the many parents of
children suffering the highest rate of cancer, brain cancer. In
1999 theWHO through the IARC listed the aluminum in vaccines as
a grade 3 out of 4 carcinogens. It doesn’t help either to
understand now that aluminum will increase the permeability of
the blood brain barrier and allow viruses (viruses that have an
affinity for the central nervous system like measles) into the
brain along with the mercury and aluminum - both metals that can
act synergistically to mutate. Seriously, they still don’t see
where the rise in childhood brain cancer is coming from?
Aluminum in the vaccines is also
up regulating the IgE and compromising the IgA, therefore the
presence of aluminum in the vaccines is a much involved gene
impactor which causes vaccines to result in
allergies, atopy,
anaphylaxis, asthma and eczema expression. The natural immune
system has a variety of defense tools to use in the protection
of the organism however these systems are dys regulated when
damaged pathways result from damaged pathogens or genetically
engineered pathogens are artificially introduced.
The effects of alum were never
known even though the toxin has enjoyed a hierarchical rise in
use and success. The amount used in vaccines is not a “safe”
amount, it is only the amount they found necessary to exert its
inflammatory effect as an adjuvant! The lack of safety studies,
lack of teratogenicity or carcinogenic studies or any long term
effects signaling genetic defects from vaccines were never done.
For any agency from the HHS, CDC, FDA, USDA,WHO, UN, UNICEF, and
GAVI to endorse or project vaccines as safe is criminal and
investigations should be called for.
Liability waivers put in
force for the drug companies to escape prosecutorial litigation
will not be upheld in the face of gross criminal action for
failure to perform due diligence in the safety study or even of
the efficacy studies that are lacking for vaccine use in the
first place. The question as to what exactly was known as
FDA-licensed products are unleashed upon the public gives rise
to another question: why is it that the drug companies that
makes vaccines and promotes their use, are the same drug
companies that make the drug for the VACCINE DISEASE that
follows the vaccine use? What exactly are the revelations that
are bound behind “proprietary confidentiality clauses” and is
this the way drug companies are pleading the Fifth Amendment for
protection from self incrimination? Would this be the reason the
governments remove vaccine liability from the manufacturers of
the experimental guise under which health care is purported?
The highly polymorphic HLA/DLA
antigen systems which are involved in antigen presentation
clearly affects responses to vaccination and therefore this
impact is unknown in any organism receiving the jab. This lack
of knowing makes every vaccination: “experimentation under
the guise of health care delivery.” Effects of vaccines on
any individual are variable and therefore any expected result
incalculable, the risk to any organism is therefore unknown.
Administering a jab is not
synonymous with conveying immunity. Antibody production is not
equated to immunity and vaccination does not mean immunization.
Damage from vaccines are cumulative, cell mediated immune
suppression increases significantly with every jab. Multivalent
vaccines are particularly damaging and immune disrupting.
Only vaccinated individuals were
found to develop auto antibodies in a landmark study done at
Perdue University. Auto antibodies are made with the vaccines
from the viruses, from the microbial antigens, from the aluminum
and mercury and other ingredients that would mutate or disrupt
the pathogen. The increase of molecular mimicry increases with
vaccines and these examples of pathways to increase the number
of auto antibodies formed the trigger necessary to promote
genetic expression of autoimmune disease. Certainly, autoimmune
disease expression is one step closer to genetic disease and
that handicap will transfer vertically to the next generation in
many instances. The important understanding is that the
adulteration of the genome came in via the injection of vaccine.
Since not even a very heavy book
could contain all the pathways to disease expression from
genetic effects of the vaccine (the great immune adulterant),
let us at least end this with the following understanding;
vaccines have no environmental epidemiological studies to
support the benefits over risks of vaccine administration, they
are not safe nor innocuous and have not even been proven
effective in conveying immunity which is the only reason
one would consider their use in the first place. Vaccination use
fits the definition of “a medical assumption” and
according to Dr. Stephen Blake is certainly the biggest medical
assumption ever made in the history of mankind and is
directly
responsible for more disease, death and disability than any
other medical procedure or act.
Not surprisingly, with the safety
of vaccination questioned and autism, autoimmune diseases and
cancer linked in hospitals to vaccinations, only now is the NIH
announcing research grants for the purpose of addressing
vaccine safety. The Research to Advance Vaccine Safety (R21)
is just now in 2010 being initiated to research vaccines:
“research that will contribute to
the overall understanding of vaccine safety such as
physiological and immunological responses to vaccines and
vaccine components, how genetic variations affect
immune/physiological responses that may impact vaccine safety
and identification of risk factors and biological markers that
may be used to access whether there is a relationship between
certain diseases or disorders and licensed vaccines and the
application of genomic/molecular technologies to improve
knowledge of vaccine safety”
The problem is that this “scientific study is too late”. For
three centuries genotoxicity, immune dysregulation and immune dysfunctioning
- even to immune deficiency and annihilation - has been de
evolving the genomes of man and animals.
Dr. Harris Coulter would consider
the vaccination as medical hubris and the many diseases spawned
from its use the “unintended consequences and collateral
damage”. The National Childhood Vaccination Program is a program
in which any parent should have the right to protect their
child. The mandatory vaccine programs are genetic assaults
and
project a form of invalid federal medicine which is tyranny.
The promotion of the vaccine programs are fraudulent and
criminal acts which no taxpayer should be made to support
as the effect in many cases, cases rising with the rise in
vaccine use, are genetic and constitute genotoxicity.
This attempt to violate the
natural laws of evolution is impacting the species in a
de-evolutionary format leading to increased genetic expression of
disease and forcing those jabbed into a cycle of chronic disease
management if not death first. Of course the
same drug companies
that make vaccines are usually the same ones that sell the
medications to palliate and suppress said disease expression.
This system of making disease and then making the medications
to suppress and palliate the disease puts into the
hands of the drug companies all the federal funds that sponsored
the vaccines and then the money from the manipulated health care
system treating the disease. Soon the allocation of funds for
the drug companies will shift the power from the democratic
state to the hands of the drug companies that have full impunity
from liability, this benefit legislated for them by the members
of the democratic legislature elected to represent those being
vaccinated into disease and harmed in the first place!
Dr. Harris Coulter stated that”
medicine” had a lot more to do with “politics” than it did with
“science”. Dr. Patricia Jordan noted that it took a Doctor
of Political Science to point out to the medical profession what
they did not seem capable of recognizing right in front of their
face, that medicine is politics and politics is about money, no
science necessary.
Any NIH research done under the
Research to Advance Vaccine Safety (R21) must have independent,
nonconflict oversight with participation of those harmed by
vaccines to ensure that the real measure of vaccine damage is
properly addressed. That is, unless the disease, disability and
deaths from vaccines were to be immediately stopped in
accordance with the Precautionary Principle.
The
precautionary principle is a moral and political principle
which states that if an action or policy might cause severe or
irreversible harm to the public or to the environment, in the
absence of a scientific consensus that harm would not ensue, the
burden of proof falls on those who would advocate taking the
action. The principle aims to provide guidance for protecting
public health and the environment in the face of uncertain
risks, stating that the absence of full scientific certainty
shall not be used as a reason to postpone measures where there
is a risk of serious or irreversible harm to public health or
the environment.
It is
obvious that the unnatural vaccine has unnaturally selected for
genes that do not reflect a natural exposure from the real
environment and thusly resulted in unnatural selection of genes
that have dys regulated the immune system and disrupted the
inflammatory pathway and distorted the populations genetically.
Unnatural gene selection is then leading to resistance and
susceptibility to disease which is unnatural and not the real
picture of the antigen state within our external environment for
which an immune system is geared to provide survivability
against encounter. Vaccination is resulting in abnormal disease
expression and the making of disease previously not encountered.
Although it is popular to blame our external environment, this
is not the main environment our immune system is being pressured
by. In the madness, the species are being distorted and genomes
are being corrupted. The rise of genetic susceptibility and
genetic disease is a reflection of this distortion. Most of what
we see today is Vaccine Disease, in that the
dysregulation of the immune system by vaccines have altered the
genetic susceptibility and expression of disease and is not
evolving a better immune system and health but deconstructing
the immune system and the genome towards doom.
http://www.thedogplace.org/Vaccines/Genetic-Impact-10073-Jordan.asp
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