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CANINE GENETICS
CHG is a fatal canine thyroid problem present in the form of a goiter at birth. 2018 stats reveal it also affects cats, sheep, goats and humans. |
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~ Barbara J. Andrews Jan. 2019 - Dr. Fyfe is currently with a research company. If you missed the first part of the interview Part 2 about CHG in the Toy Fox Terrier, you should read that first. The information below was received directly from Dr. Fyfe as Part 4 of his generous contributions to our genetic knowledge of CHG, a rare but 100% fatal condition in newborn animals.
CHG 4: Cost And Testing For Congenital Hypothyroidism With Goiter
What is this test for? (link at bottom of page explains genetic basis & cause) The test detects the presence of the gene mutation that causes CHG in Toy Fox Terriers. Using the test it is possible to identify TFT that are:
How accurate is the test? The test itself identifies the actual disease-causing mutation and is therefore totally reliable in identifying this form of CHG. If, however, a second form of hypothyroidism were to develop in the breed the test would not be able to identify it. Please take every care to follow the submission instructions and ensure that the brushes are labeled correctly.
How do I submit samples for testing? To submit brush samples for this test, the following procedure should be followed carefully:
Editor's note: We ask all breeders to contact editor to report a confirmed occurrence of GHG in any breed for our privacy protected veterinary database. We also stipulate that we do NOT agree with Dr. Fyfe's oft-quoted assessment that "over 30% of Toy Fox Terriers are affected with CHG..."
Our researchers were however able to i.d. this statement which may account for that erroneous belief.... "and 56 (31%) of 181 TFTs tested to date have been identified as carriers. However, this percentage does not reflect a true carrier prevalence or gene frequency because a large bias in sample submission likely has occurred. In the population sample tested to date, a popular sire effect has been found on the distribution of CHG carriers that is recognized by many breeders and has created a significant motivation for testing." source credit https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1939-1676.2003.tb01323.x (offsite link, copy and paste URL in browser)
As is so correctly stated, a breeder or owner would be unlikely to have a dog tested for a condition which is fatal and readily discernable if present. If however, a dog had an affected or carrier relative, it would be prudent to test to determine if it too is a carrier.
For more information on other breeds (and species) affected by Congenital Hypothyroidism with Goiter, see Part 1 - CHG Introduction.
Part 2 - About Congenital Hypothyroidism with Goiter (CHG) Part 3 - CHG-3 Genetic Basis, by Dr.Fyfe Copyright © TheDogPlace.org 1411r12 http://www.thedogplace.org/GENETICS/CHG-3-Congenital-Hypothyroidism-testing-cost-Fyfe-DVM.asp
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